Natural Products as Antiviral Agents: Proceedings of an American Chemical Societ

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The Nile on eBay FREE SHIPPING UK WIDE Natural Products as Antiviral Agents by C.K. Chu, H.G. Cutler During the past fifty years, thousands of natural products have been isolated from plants, fungi, and bacteria. FORMAT Hardcover LANGUAGE English CONDITION Brand New Publisher Description During the past fifty years, thousands of natural products have been isolated from plants, fungi, and bacteria. Apart from intense searches by pharmaceutical companies for medicinals and the concentrated effort mounted by the National Cancer Institute, many of these have not been tested in biological systems. The major reasons for this appear to be, at least, twofold. First, individual researchers looking for biologically active natural products will often isolate only small amounts of material sufficient to determine a structure and calculate the specific activity for their particular bioassay systems: insufficient funds preclude re-isolating the compound unless industrial potential is foreseen. Second, the difficulty with which original structures were proved prior to 1972. This required the isolation of relatively large quantities of a natural product and there followed extensive degradation, elemental analyses of the parent and its fragments, then synthesis, piece by piece, of the molecule. All this took time and energy. No wonder that when the structure was proved the chemist was enervated. And coupled to this was the fact that many chemists were not trained to test their materials in biological systems. In contrast, today a natural product can be isolated, its mass and molecular formula determined and, if there is some serendipity, crystals may be obtained for single crystal x-ray analysis. If conditions are near perfect, it is possible to isolate and identify a novel compound in a month. Table of Contents Progress in the Development of Natural Products for Human Immunodeficiency Viruses Infections.- Structure-Activity Correlations of Natural Products with Anti-HIV Activity.- Aids-Antiviral Natural Products Research at the U.S. National Cancer Institute.- Tannins and Related Compounds as Anti-HIV Agents.- Mode of Action of Hypericin as an Antiretroviral Agent and Other Relevant Findings.- Activity of Selected Amaryllidaceae Constituents and Related Synthesis Substances against Medically Important RNA Viruses.- Aminosugar Attenuation of HIV Infection.- Plant Proteins with Antiviral Activity against Human Immunodeficiency Virus.- Antiviral Studies with Trichosanthin, A Plant Derived Single Chain Ribosome Inactivating Protein.- Screening of Natural Products as HIV-1 and HIV-2 Reverse Transcriptase (RT) Inhibitors.- Natural Products as Anti-HIV Agents.- Antiviral Activity of Natural Phloroglucinols and Their Analogues.- The Indole Alkaloid Tumor Promoter Teleocidins as Epstein-Barr Virus Inducers: Structure, Biosynthesis and Structure-Activity Relationship. Long Description During the past fifty years, thousands of natural products have been isolated from plants, fungi, and bacteria. Apart from intense searches by pharmaceutical companies for medicinals and the concentrated effort mounted by the National Cancer Institute, many of these have not been tested in biological systems. The major reasons for this appear to be, at least, twofold. First, individual researchers looking for biologically active natural products will often isolate only small amounts of material sufficient to determine a structure and calculate the specific activity for their particular bioassay systems: insufficient funds preclude re-isolating the compound unless industrial potential is foreseen. Second, the difficulty with which original structures were proved prior to 1972. This required the isolation of relatively large quantities of a natural product and there followed extensive degradation, elemental analyses of the parent and its fragments, then synthesis, piece by piece, of the molecule. All this took time and energy. No wonder that when the structure was proved the chemist was enervated. And coupled to this was the fact that many chemists were not trained to test their materials in biological systems. In contrast, today a natural product can be isolated, its mass and molecular formula determined and, if there is some serendipity, crystals may be obtained for single crystal x-ray analysis. If conditions are near perfect, it is possible to isolate and identify a novel compound in a month. Details ISBN 0306443465 ISBN-10 0306443465 ISBN-13 9780306443466 Format Hardcover Subtitle Proceedings of an American Chemical Society Agricultural and Food Chemistry Division Symposium Held in New York, August 27, 1991 Place of Publication Dordrecht Short Title NATURAL PRODUCTS AS ANTIVIRAL Language English Media Book DEWEY 615 DOI 10.1604/9780306443466 Pages 279 Year 1992 Edition 1992nd Publication Date 1992-12-31 Illustrations VIII, 279 p. AU Release Date 1992-12-31 NZ Release Date 1992-12-31 US Release Date 1992-12-31 UK Release Date 1992-12-31 Author H.G. Cutler Edited by H.G. Cutler Edition Description 1992 ed. Alternative 9781461365099 Audience Undergraduate Country of Origin US Product Class Description Clinical Medicine: Professional Publisher Kluwer Academic Publishers Group Imprint Kluwer Academic / Plenum Publishers Country of Publication Netherlands We've got this At The Nile, if you're looking for it, we've got it. 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