Ethical Challenges in Human Research by Franklin G Miller 2012 Hardcover

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brand: Oxford University Press, Incorporated Dewey Decimal: 174.2/8 Publisher: Oxford University Press, Incorporated ISBN-10: 0199896208 Item Width: 6.3 in Reviews: "The articles in this book are seminal contributions to research ethics thought, especially since they challenge numerous prevailing assumptions in research ethics scholarship." -- DOODY'S, "The articles in this book are seminal contributions to research ethics thought, especially since they challenge numerous prevailing assumptions in research ethics scholarship." -- DOODY'S"Of the three main areas of research in applied ethics -- medical ethics, business ethics, and environmental ethics -- medical ethics has received the most sustained philosophical attention. But not all issues in medical ethics have received the same degree of philosophical scrutiny, and while much attention has been paid to ethical issues that concern the provision of medical care, comparatively little attention has been paid to ethical issues that arise in the course of clinical research... There is thus much of value in The Ethical Challenges of Human Research, and it serves as a welcome corrective to the more usual bioethical focus on medical care." -- James Stacey Taylor, The College of New Jersey, Notre Dame Philosophical Reviews, "The articles in this book are seminal contributions to research ethics thought, especially since they challenge numerous prevailing assumptions in research ethics scholarship." -- DOODY'S "Of the three main areas of research in applied ethics -- medical ethics, business ethics, and environmental ethics -- medical ethics has received the most sustained philosophical attention. But not all issues in medical ethics have received the same degree of philosophical scrutiny, and while much attention has been paid to ethical issues that concern the provision of medical care, comparatively little attention has been paid to ethical issues that arise in the course of clinical research... There is thus much of value in The Ethical Challenges of Human Research, and it serves as a welcome corrective to the more usual bioethical focus on medical care." -- James Stacey Taylor, The College of New Jersey, Notre Dame Philosophical Reviews, "The articles in this book are seminal contributions to research ethics thought, especially since they challenge numerous prevailing assumptions in research ethics scholarship." -- DOODY'S"Of the three main areas of research in applied ethics -- medical ethics, business ethics, and environmental ethics -- medical ethics has received the most sustained philosophical attention. But not all issues in medical ethics have received the same degree of philosophical scrutiny, and while much attention has been paid to ethical issues that concern the provision of medical care, comparatively little attention has been paid to ethical issues that arise inthe course of clinical research... There is thus much of value in The Ethical Challenges of Human Research, and it serves as a welcome corrective to the more usual bioethical focus on medical care." --James Stacey Taylor, The College of New Jersey, Notre Dame Philosophical Reviews Subject Area: Medical Type: Textbook Item Length: 9.3 in Subject: Ethics, Clinical Medicine Author: Franklin G. Miller LC Classification Number: W 20.55.H9 gtin13: 9780199896202 Format: Hardcover ISBN-13: 9780199896202 Dewey Edition: 23 Publication Year: 2012 Publication Name: Ethical Challenges of Human Research : Selected Essays Item Height: 1.3 in Number of Pages: 448 Pages Synopsis: The use of human beings as research subjects poses distinctive ethical issues. Subjects of medical research are exposed to risks of harm for the sake of generating scientific knowledge that can benefit future patients and society. Ethical analysis of the challenges posed by research involving human subjects requires careful attention to the contextual details of scientific experimentation. This book contains 22 essays by Franklin G. Miller on research ethics written over a 15-year period. With the exception of the first essay, all have been previously published in bioethics and medical journals. The book is arranged into four parts. Part One addresses a general ethical perspective on the protection of human subjects in clinical research, including paternalism in research regulation and acceptable limits to research risks. The essays in Part Two examine ethical issues in study design. It includes ethical analyses of controversial types of medical experimentation-studies that provoke psychiatric symptoms, induce infections, provide patients with placebos that withhold proven effective treatments or administer fake invasive procedures, test experimental treatments in cancer patients who have exhausted all standard treatment options, and employ the use of deception to generate scientifically valid data. Part Three offers a systematic critique of "the therapeutic orientation" to clinical trials and the principle of clinical equipoise, which is widely regarded as a fundamental norm for randomized treatment studies. Part Four takes up a range of ethical issues relating to informed consent for research participation, including examination of "the therapeutic misconception" and presentation of a novel approach to the validity of consent: "the fair transaction model." An abiding theme, developed in many of the essays is that the ethics of clinical research is importantly different from the ethics of medical care., This book contains 22 essays on the ethics of research involving human subjects written over a 15-year period. Topics addressed include the ethics of clinical trials, controversial study designs, and informed consent. Table Of Content: PrefaceAcknowledgmentsPart One: Protecting Human Subjects in Clinical Research: A General Perspective1. Situating research ethics: revisiting Beecher and Jonas2. Facing up to paternalism in research ethics. Hastings Center Report 2007;37(3):24-343. Limits to research risks. Journal of Medical Ethics 2009;35:445-449Part Two: Study Design4. Psychiatric symptom-provoking studies: an ethical appraisal. Biological Psychiatry. 1997;42:403-95. The ethical challenge of infection-inducing challenge experiments. Clinical Infectious Diseases. 2001;33:1028-336. Placebo-controlled trials in psychiatric research: an ethical perspective. Biological Psychiatry. 2000;47:707-167. What makes placebo-controlled trials unethical? The American Journal of Bioethics. 2002;2(2):3-8. Ethical issues concerning research on complementary and alternative medicine. JAMA 2004;291:599-6049. Sham surgery: an ethical analysis. American Journal of Bioethics 2003;3(4):41-810. Benefit in phase 1 oncology trials: therapeutic misconception or reasonable treatment option? Clinical Trials 2008;5:617-2311. Deception in research on the placebo effect. PLoS Medicine 2005;2(9):e26212. Debriefing and accountability in deceptive research. Kennedy Institute of Ethics Journal 2008;18:235-51Part Three: Therapeutic Orientation and Equipoise13. Professional integrity in clinical research. Journal of the American Medical Association. 1998;280:1449-5414. The therapeutic orientation to clinical trials. New England Journal of Medicine. 2003;348:1383-8615. A critique of clinical equipoise: Therapeutic misconception in the ethics of clinical trials. Hastings Center Report. 2003;33(3):19-2816. Clinical equipoise and the incoherence of research ethics. Journal of Medicine and Philosophy 2007;32:151-6517. Equipoise and the randomized clinical trial dilemma. New England Journal of Medicine 2011;364:476-80Part Four: Consent18. Evaluating the therapeutic misconception. Kennedy Institute of Ethics Journal 2006;16:353-6619. Is it ethical to keep interim findings of randomized controlled trials confidential? Journal of Medical Ethics 2008;34:198-220. Research on medical records without informed consent, Journal of Law, Medicine and Ethics 2008;36:560-6621. Coverage with evidence development: ethical issues and policy implications. Medical Care 2008;46:746-5722. The fair transaction model of informed consent: an alternative to autonomous authorization, Kennedy Institute of Ethics Journal 2011;21:201-18 Language: English LCCN: 2012-008758 Item Weight: 21.2 Oz Intended Audience: Scholarly & Professional TitleLeading: The

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  1. This thought-provoking collection by Franklin G. Miller dives deep into the ethical dilemmas of human research with clarity and insight. The essays are well-structured, engaging, and essential for anyone interested in bioethics. The hardcover edition arrived in perfect condition, and free shipping was a nice bonus! Highly recommend for students and professionals alike.

    Michał Adamczyk