Fundamentals of Neurodegeneration and Protein Misfolding Diso... - 9783319342849-image

Fundamentals of Neurodegeneration and Protein Misfolding Diso... - 9783319342849

$ 54.65

Country of Origin: Germany ISBN: 9783319342849 gtin13: 9783319342849

Description

Fundamentals of Neurodegeneration and Protein Misfolding Disorders Please note: this item is printed on demand and will take extra time before it can be dispatched to you (up to 20 working days). Author(s): Martin Beckerman Format: Paperback Publisher: Springer International Publishing AG, Switzerland Imprint: Springer International Publishing AG ISBN-13: 9783319342849, 978-3319342849 Synopsis This unique text introduces students and researchers to the world of misfolded proteins, toxic oligomers, and amyloid assemblages, and the diseases of the brain that result. During the past few years the connections between failures in protein quality control and neurological disorders have been reinforced and strengthened by discoveries on multiple [url] findings provide novel insights on how amyloidogenic oligomers and fibrils form, interconvert from one state to another, and propagate from cell to cell and region to region. Starting with protein folding and protein quality control basics, the reader will learn how misfolded proteins can cause diseases ranging from prion diseases to Alzheimers disease and Parkinsons disease to Huntingtons disease, amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Authoritative butwritten in a clear and engaging style, Fundamentals of Neurodegeneration and Protein Misfolding Disordersaddresses one of todays forefront areas of science and medicine. The text emphasizes the new groundbreaking biophysical and biochemical methods that enable molecular-level explorations and the conceptual breakthroughs that result. It contains separate chapters on each of the major disease classes. Special emphasis is placed on those factors and themes that are common to the diseases, especially failures in synaptic transmission, mitochondrial control, and axonal transport; breakdowns in RNA processing; the potential role of environmental factors; and the confounding effects of neuroinflammation. The book is ideal for use in teaching at the advanced undergraduate and graduate levels, and serves as a comprehensive reference for a broad audience of students and researchers in neuroscience, molecular biology, biological physics and biomedical engineering.

  1. Ordered on 10th, delivered on 18th. In described condition and excellent price. Delivered by Amazon - the tracking number link didn't work so couldn't track its progress. Package was also left outside on the pavement in the dark despite lights being on at the front door. Would have been a big problem if it was raining as the packaging is cardboard although the book itself was in polythene. When I queried the problem with the tracking number buyer did respond quickly so good comms.

    Cường Dương Thái

  2. Good seller, ⭐️⭐️⭐️⭐️⭐️ item as described, packaging average, delivery was a huge disappointment as it was thrown at my front door by an AMAZON driver. I purchased via eBay to avoid AMAZON, now they are involved leaving our eBay purchases on our doorsteps. I do have cctv of the driver throwing my package. I brought the poor delivery to the attention of the seller who advised they would contact the delivery organisation concerned about the breach in their delivery instructions.

    Relatively Uncertain

  3. This new book I ordered was poorly packaged & arrived in a cardboard wrap which was wide open & the pages had bent & damaged corners. I contacted the seller who sent a return label & arranged for a new replacement to be sent out. The new book arrived in great condition a few days later. Very happy with their communication & the way they resolved my issue quickly. I wouldn't hesitate to shop with them again. Thank you for the great customer service.

    Tyler David Shmosh

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