Cancer Clinical Trials : Current and Controversial Issues in Design and Analy...-image

Cancer Clinical Trials : Current and Controversial Issues in Design and Analy...

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Publication Year: 2016 ISBN: 9781498706889 Item Length: 9.4 in Subject Area: Mathematics, Medical Number of Pages: 454 Pages Book Title: Cancer Clinical Trials : Current and Controversial Issues in Desi Format: Hardcover Type: Textbook Item Weight: 27.3 Oz Publication Name: Cancer Clinical Trials : Current and Controversial Issues in Design and Analysis height: 1.2 in Subject: Clinical Medicine, Probability & Statistics / General, Oncology, Pharmacology Author: Xiaofei Wang Item Width: 6.2 in Publisher: CRC Press LLC Item Height: 1.2 in Series: Chapman and Hall/Crc Biostatistics Ser. width: 6.2 in Language: English

Description

Cancer Clinical Trials : Current and Controversial Issues in Design and Analy.... The first of four sections discusses general issues with design and data analysis including endpoints, use of historical data, multiplicity, and safety analysis. Annotation ©2016 Ringgold, Inc., Portland, OR (). Cancer Clinical Trials : Current and Controversial Issues in Design and Analysis, Hardcover by George, Stephen L. (EDT); Wang, Xiaofei (EDT); Pang, Herbert (EDT), ISBN 1498706886, ISBN-13 9781498706889, Brand New, Free shipping in the US George, Wang, and Pang edit this compilation on contemporary methodological controversies in cancer clinical trial design. The first of four sections discusses general issues with design and data analysis including endpoints, use of historical data, multiplicity, and safety analysis. Section two focuses on issues particular to early phase clinical trials including validation of biomarker assays, dose-finding in Phase I, and one-stage vs two-stage designs in Phase II. Section three addresses late phase trials, discussing sample size determination for survival analysis, non-inferiority, and quality of life measures. The final section touches on issues in the emerging field of personalized medicine including performance of biomarkers, adaptive trial design, and dynamic treatment regimens. Annotation ©2016 Ringgold, Inc., Portland, OR ()

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