Phenotyping of Human Ipsc-derived Neurons : Patient-driven Research, Paperbac...-image

Phenotyping of Human Ipsc-derived Neurons : Patient-driven Research, Paperbac...

$ 149.39

Subject Area: Science, Medical Publisher: Elsevier Science & Technology ISBN: 9780128222775 Publication Name: Phenotyping of Human Ipsc-Derived Neurons : Patient-Driven Research gtin13: 9780128222775 Item Width: 7.5 in Language: English Item Length: 9.2 in Subject: Neuroscience, Life Sciences / Neuroscience Number of Pages: 350 Pages Format: Trade Paperback Type: Textbook Author: Elizabeth D. Buttermore Publication Year: 2022 Book Title: Phenotyping of Human Ipsc-derived Neurons : Patient-driven Resear

Description

Phenotyping of Human Ipsc-derived Neurons : Patient-driven Research, Paperback by Buttermore, Elizabeth D. (EDT), ISBN 0128222778, ISBN-13 9780128222775, Like New Used, Free shipping in the US Phenotyping of Human iPSC-derived Neurons: Patient-Driven Research examines the steps in a preclinical pipeline that utilizes iPSC-derived neuronal technology to better understand neurological disorders and identify novel therapeutics, also providing considerations and best practices. By presenting example projects that identify phenotypes and mechanisms relevant to autism spectrum disorder and epilepsy, this book allows readers to understand what considerations are important to assess at the start of project design. Sections address reproducibility issues and advances in technology at each stage of the pipeline and provide suggestions for improvement. From patient sample collection and proper controls to neuronal differentiation, phenotyping, screening, and considerations for moving to the clinic, these detailed descriptions of each stage of the pipeline will help everyone, regardless of stage in the pipeline. In recent years, drug discovery in the neurosciences has struggled to identify novel therapeutics for patients with varying indications, including epilepsy, chronic pain, and psychosis. Current treatment options for such patients are decades old and offer little relief with many side effects. One explanation for this lull in novel therapeutics is a lack of novel target identification for neurological disorders (and target identification requires exemplar preclinical data). To improve on the preclinical work that often relies on rodent modeling, the field has begun utilizing patient-derived induced pluripotent stem cells (iPSCs) to differentiate neurons in vitro for preclinical characterization of neurological disease and target identification. Discusses techniques and new technology for iPSC culturing and neuronal differentiation to establish best practices in the lab Outlines considerations for phenotypic assay development Provides information about the successes, failures, and implications of phenotyping and screening with iPSC-derived neurons Describes how human iPSC-derived neurons are being used for preclinical discovery research as well as the development of therapeutics utilizing hiPSC-derived neurons

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