Targeting the Broadly Pathogenic Kynurenine Pathway - 9783319363219-image

Targeting the Broadly Pathogenic Kynurenine Pathway - 9783319363219

$ 73.98

gtin13: 9783319363219 ISBN: 9783319363219 Country of Origin: United States

Description

Targeting the Broadly Pathogenic Kynurenine Pathway Please note: this item is printed on demand and will take extra time before it can be dispatched to you (up to 20 working days). Author(s): Sandeep Mittal Format: Paperback Publisher: Springer International Publishing AG, Switzerland Imprint: Springer International Publishing AG ISBN-13: 9783319363219, 978-3319363219 Synopsis Tryptophan metabolism via kynurenine pathway plays a critical role in both health and a variety of human diseases. This book highlights the known associations between kynurenine pathway andvarious disease states, as well as examines the current status of drug development and clinical trials of compounds known to alter tryptophan metabolism. The research plays a critical role in molecular targeted therapies directed at altering the kynurenine pathway of tryptophan [url] initial and rate-limiting step of tryptophan metabolism is mediated by one of two enzymes, tryptophan-2,3-dioxygenase (TDO; predominantly in the liver, but also in the brain) and indoleamine-2,3-dioxygenase (IDO; in a host of tissues in response to immune activation). Targeting the enzymes IDO and TDO, as well as other downstream effectors would therefore be likely to generate novel treatment options that would be helpful in a wide variety of clinical settings. This book provides a unique bridge between basic mechanistic understanding of the role of the kynurenine pathway with translational applications and clinical relevance. It will explore the indications that tryptophan metabolism is a potential biomarker of disease activity, can contribute to local and possibly systemic immune suppression in cancer, and is an attractive target for which a variety of inhibitors are readily available.

  1. Ordered on 10th, delivered on 18th. In described condition and excellent price. Delivered by Amazon - the tracking number link didn't work so couldn't track its progress. Package was also left outside on the pavement in the dark despite lights being on at the front door. Would have been a big problem if it was raining as the packaging is cardboard although the book itself was in polythene. When I queried the problem with the tracking number buyer did respond quickly so good comms.

    Cường Dương Thái

  2. Good seller, ⭐️⭐️⭐️⭐️⭐️ item as described, packaging average, delivery was a huge disappointment as it was thrown at my front door by an AMAZON driver. I purchased via eBay to avoid AMAZON, now they are involved leaving our eBay purchases on our doorsteps. I do have cctv of the driver throwing my package. I brought the poor delivery to the attention of the seller who advised they would contact the delivery organisation concerned about the breach in their delivery instructions.

    Relatively Uncertain

  3. This new book I ordered was poorly packaged & arrived in a cardboard wrap which was wide open & the pages had bent & damaged corners. I contacted the seller who sent a return label & arranged for a new replacement to be sent out. The new book arrived in great condition a few days later. Very happy with their communication & the way they resolved my issue quickly. I wouldn't hesitate to shop with them again. Thank you for the great customer service.

    Tyler David Shmosh

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