Bioorganic Chemistry of Biological Signal Transduction by Herbert Waldmann (Engl-image

Bioorganic Chemistry of Biological Signal Transduction by Herbert Waldmann (Engl

$ 57.49

ISBN-13: 9783540677468 ISBN: 9783540677468 gtin13: 9783540677468 Book Title: Bioorganic Chemistry of Biological Signal Transduction

Description

The Nile on eBay FREE SHIPPING UK WIDE Bioorganic Chemistry of Biological Signal Transduction by Herbert Waldmann, G. Dorman, P.J. Hergenrother, C. Herrmann, J. Kuhlmann, A. Levitzki, S.F. Martin, M. Thutewohl, G. Müller This series presents critical reviews of the present position and future trends in modern chemical research. FORMAT Hardcover LANGUAGE English CONDITION Brand New Publisher Description The transduction of signals from the extracellular space across the plasma membrane into the interior of cells and ultimately to the nucleus, where in - sponse to such external signals the transcription of the genetic code is inf- enced,belongs to the most fundamental and important events in the regulation of the life cycle of cells. During recent years several signal transduction cascades have been elucidated which regulate,for instance,the growth and the prolife- tion of organisms as diverse as mammals, flies, worms and yeast. The general picture which emerged from these investigations is that nature employs a c- bination of non-covalent ligand/protein and protein/protein interactions together with a set of covalent protein modifications to generate the signals and transduce them to their destinations. The ligands which are recognized may be low molecular weight compounds like lipids, inositol derivatives, steroids or microbial products like cyclosporin. They may be proteins like, for instance, growth factors or intracellular adaptor proteins which carry SH2 or SH3 domains, and they may be specific DNA stretches which are selectively rec- nized by transcription factors.These and other aspects of biological signal transduction provide an open and rewarding field for investigations by scientists from various different dis- plines of biology,medical research and chemistry working in academic research institutions or in industry. Table of Contents Protein Tyrosine Kinase Inhibitors as Therapeutic Agents.- Peptidomimetic SH2 Domain Antagonists for Targeting Signal Transduction.- Biophysical Characterization of the Ras Protein.- Ras-Farnesyltransferase-Inhibitors as Promising Anti-Tumor Drugs.- Phosphatidylcholine-Preferring Phospholipase C from B. cereus. Function, Structure, and Mechanism.- Photoaffinity Labeling in Biological Signal Transduction. Long Description The transduction of signals from the extracellular space across the plasma membrane into the interior of cells and ultimately to the nucleus, where in - sponse to such external signals the transcription of the genetic code is inf- enced,belongs to the most fundamental and important events in the regulation of the life cycle of cells. During recent years several signal transduction cascades have been elucidated which regulate,for instance,the growth and the prolife- tion of organisms as diverse as mammals, flies, worms and yeast. The general picture which emerged from these investigations is that nature employs a c- bination of non-covalent ligand/protein and protein/protein interactions together with a set of covalent protein modifications to generate the signals and transduce them to their destinations. The ligands which are recognized may be low molecular weight compounds like lipids, inositol derivatives, steroids or microbial products like cyclosporin. They may be proteins like, for instance, growth factors or intracellular adaptor proteins which carry SH2 or SH3 domains, and they may be specific DNA stretches which are selectively rec- nized by transcription factors. These and other aspects of biological signal transduction provide an open and rewarding field for investigations by scientists from various different dis- plines of biology,medical research and chemistry working in academic research institutions or in industry. Feature This series presents critical reviews of the present position and future trends in modern chemical research Short and concise reports on chemistry, each written by the world renowned experts Still valid and useful after 5 or 10 years Details ISBN 3540677461 Publisher Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Series Topics in Current Chemistry Year 2000 ISBN-10 3540677461 ISBN-13 9783540677468 Format Hardcover Publication Date 2000-10-18 Imprint Springer-Verlag Berlin and Heidelberg GmbH & Co. K Place of Publication Berlin Country of Publication Germany DEWEY 572 Pages 230 Edition 2001st Language English Media Book DOI 10.1007/b68639 Series Number 211 UK Release Date 2000-10-18 Author G. Müller Edition Description 2001 ed. Alternative 9783662146972 Edited by Herbert Waldmann Audience Undergraduate Illustrations 94 Illustrations, black and white; IX, 230 p. 94 illus. With online files/update. Country of Origin DE Product Class Description Chemistry We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! 30 DAY RETURN POLICY No questions asked, 30 day returns! FREE DELIVERY No matter where you are in the UK, delivery is free. SECURE PAYMENT Peace of mind by paying through PayPal and eBay Buyer Protection TheNile_Item_ID:158856156;

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