MicroRNA in Development and in the Progression of Cancer by Shree Ram Singh (Eng-image

MicroRNA in Development and in the Progression of Cancer by Shree Ram Singh (Eng

$ 207.03

ISBN: 9781489980649 gtin13: 9781489980649 ISBN-13: 9781489980649 Book Title: MicroRNA in Development and in the Progression of Cancer

Description

The Nile on eBay FREE SHIPPING UK WIDE MicroRNA in Development and in the Progression of Cancer by Shree Ram Singh, Pranela Rameshwar Altered expression of particular miRNAs has been implicated in the onset and development of cancer and could be used as potential biomarkers for the disease.Recently, many studies have found miRNAs have crucial regulatory roles in Cancer stem cells (CSCs) a kind of tumor initiating cells (TICs) and dormancy. FORMAT Hardcover LANGUAGE English CONDITION Brand New Publisher Description miRNAs are a class of endogenous, small non-protein coding RNA molecules (~ 22 nucleotides) which are novel post-transcriptional regulators of gene expression. Since we have hundreds of miRNAs, the major challenge is now to understand their specific biological function. In fact the experimental evidence suggests that signaling pathways could be ideal candidates for miRNA-mediated regulation. Several studies suggest that miRNAs affect the responsiveness of cells to signaling molecules such as WNT, Notch, TGF-β and EGFR. Altered expression of particular miRNAs has been implicated in the onset and development of cancer and could be used as potential biomarkers for the disease.Recently, many studies have found miRNAs have crucial regulatory roles in Cancer stem cells (CSCs) a kind of tumor initiating cells (TICs) and dormancy. Findings also suggest that DNA methylation may be important in regulating the expression of many miRNAs in several cancer initiating cells. Several miRNAs are known to either upregulated or downregulated in CSCs when compared to non-cancerous cells from the same tissues. CSCs are a small subpopulation of cells identified in a variety of tumors and involve in self-renewal, differentiation, chemoresistance and tumorigenesis. The volume will give a comprehensive account of important advancements in the area of miRNAs and cancer. Back Cover MicroRNAs (miRNAs) are small 22-nucleotides long non-coding RNAs that regulate the gene expression through translational repression and mRNA degradation in varieties of species. miRNAs play regulatory role in several fundamental biological processes from normal development to regulation of stem cells, cancer stem cells and various human diseases including cancer. miRNAs can be used as potential biomarkers for disease diagnosis and have been considered potential therapeutic strategies in cancer treatment. This is a timely and specialized book providing the current understanding of miRNAs and their potential application in cancer diagnosis, prognosis, and therapeutic strategies in cancer treatment. This book will be a valuable source of information for the scientists in the field of cancer research as well as undergraduate and graduate students who want to pursue their research careers in cancer biology. Table of Contents Preface.- miRNA biogenesis and function.- miRNAs in cancer progression.- MicroRNA, DNA repair and cancer.- Role of microRNAs in stem cells regulation and tumorigenesis in Drosophila.- MicroRNAs in stem cells and cancer stem cells.- MicroRNAs in epithelial mesenchymal transition and breast cancer progression.- MicroRNAs in the development and progression of breast cancer.- The role of microRNAs in hematopoietic stem cells and leukemia development.- MiRNA and chronic lymphocytic leukemia.- The role of miRNAs in the development of normal pancreas and pancreatic cancer, and their roles in tumor progression.- Epigenetic regulation of microRNA genes in colorectal cancer.- MicroRNAs in the development and progression of kidney cancer.- MicroRNAs in the development and progression of skin cancer.- MicroRNAs in the Development and Progression of Prostate Cancer.- MicroRNAs in development and progression of ovarian cancer.- MicroRNA and Cancer Drug Resistance.- Microvesicular Transfer of microRNA in Tumor Microenvironment.- MicroRNA cancer therapeutics and the challenge of drug delivery.- MicroRNA and Drug Delivery.- Index. Feature Provides a more complete understanding of miRNAs function Explore how miRNAs regulate normal development, diseases including cancers and stem cells fate Presents the great potential of miRNAs in CSCs and potential therapeutic advances for cancer Details ISBN 1489980644 Short Title MICRORNA IN DEVELOPMENT & IN T Language English ISBN-10 1489980644 ISBN-13 9781489980649 Media Book Format Hardcover Year 2014 Publication Date 2014-04-21 Imprint Springer-Verlag New York Inc. Place of Publication New York Country of Publication United States Edited by Pranela Rameshwar Author Pranela Rameshwar Pages 407 Edition 2014th Illustrations 38 Illustrations, color; 9 Illustrations, black and white; XIII, 407 p. 47 illus., 38 illus. in color. DOI 10.1007/978-1-4899-8065-6 AU Release Date 2014-04-21 NZ Release Date 2014-04-21 US Release Date 2014-04-21 UK Release Date 2014-04-21 Publisher Springer-Verlag New York Inc. Edition Description 2014 ed. Alternative 9781493944910 DEWEY 616.994042 Audience Professional & Vocational Country of Origin NL Product Class Description Clinical Medicine: Professional We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! 30 DAY RETURN POLICY No questions asked, 30 day returns! FREE DELIVERY No matter where you are in the UK, delivery is free. SECURE PAYMENT Peace of mind by paying through PayPal and eBay Buyer Protection TheNile_Item_ID:137805356;

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