Resistance of Cancer Cells to Ctl-mediated Immunotherapy, Hardcover by Bonavi...-image

Resistance of Cancer Cells to Ctl-mediated Immunotherapy, Hardcover by Bonavi...

$ 63.81

Publication Name: Resistance of Cancer Cells to Ctl-Mediated Immunotherapy ISBN: 9783319178066 Item Width: 6.1 in Publication Year: 2015 Publisher: Springer International Publishing A&G width: 6.1 in Series: Resistance to Targeted Anti-Cancer Therapeutics Ser. Type: Textbook Item Length: 9.3 in Author: Benjamin Bonavida Subject Area: Medical Number of Pages: Xix, 353 Pages Subject: Microbiology, Oncology, Research Item Weight: 266 Oz Language: English Format: Hardcover Book Title: Resistance of Cancer Cells to Ctl-mediated Immunotherapy

Description

Resistance of Cancer Cells to Ctl-mediated Immunotherapy, Hardcover by Bonavi.... Resistance of Cancer Cells to Ctl-mediated Immunotherapy, Hardcover by Bonavida, Benjamin (EDT); Chouaib, Salem (EDT), ISBN 3319178067, ISBN-13 9783319178066, Brand New, Free shipping in the US This comprehensive volume explores the latest research on the mechanisms of resistance in cancer cells to CTL-mediated immunotherapy. Chapter topics discuss cell-mediated immunity as the result of cytotoxic T-lymphocytes (CTL) directed specifically against cancer cells. In addition, the volume reviews how CTL mediate the cytotoxic activity, in large part, by the indication of apoptosis; hence, tumor cells develop anti-apoptotic mechanisms and thereby, resist CTL-induced apoptosis. In order for CTL-mediated antitumor immunotherapy to be effective, it is essential that agents directed against the resistant tumor cells sensitized cancer cells for CTL-mediated apoptosis. Examples of such agents discussed in the volume include are HDAC inhibitors, proteasome inhibitors, Bcl-2 family inhibitors, PARP, antibodies, and more.

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